SP1通过直接结合ADAMTS-8启动子抑制其表达，促进结直肠癌和骨肉瘤进展，临床数据显示低ADAMTS-1与不良预后相关，Mitramycin A可逆转SP1对ADAMTS-8的抑制作用。 ADAMTS-8的表观遗传沉默与肿瘤侵袭性的增加和不良预后相关；然而，其在癌症中的转录调控机制仍很大程度上 ...

隐源性卒中患者中严重ADAMTS-13缺乏症（CISAD）的回顾性研究，纳入9例确诊患者，均表现为无溶血性贫血的缺血性卒中，接受血浆置换、激素和利妥昔单抗治疗。结果显示CISAD可表现为ESUS，早期检测有助于降低复发风险，强调ADAMTS-13检测在隐源性卒中诊断中的重要性 ...

【导读】肺腺癌（LUAD）是肺癌的主要亚型。LUAD患者的预后不佳主要是由于转移所致。ADAMTS16是ADAMTS家族的重要成员，参与肿瘤进展。然而，其在LUAD中的作用和调节机制尚未被研究。 11月17日，华中科技大学刘博研究团队在期刊《Cell Death&Disease》上发表了研究论文 ...

在一项新的研究中，来自美国圣犹大儿童研究医院和中国广州医科大学第一附属医院等研究机构的研究人员鉴定出成纤维细胞在流感病毒和其他呼吸道病原体感染后的肺部炎症免疫反应中起着重要作用。他们正在开展进一步的研究，以将这些发现转化为治疗方法 ...

The ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) family comprises a group of extracellular zinc-dependent endopeptidases that modulate the structure and function of the ...

2020年11月11日讯/生物谷BIOON/---在一项新的研究中，来自美国圣犹大儿童研究医院和中国广州医科大学第一附属医院等研究机构 ...

There is the Addams Family. And then there is the ADAMTS family. While one is mindless entertainment, the latter may prove to be a new genetic avenue for designing ovarian cancer treatment. Scientists ...

The findings suggest recombinant ADAMTS-13 may be a useful adjunct therapy to plasma exchange among patients who have thrombotic thrombocytopenic purpura (iTTP). Clearance of ADAMTS-13 mediated by ...

Finally, the molecular pathways involved were investigated. Adamts-7 overexpression led to increased expression of TNF and metalloproteinases associated with the development of OA. In addition, via ...

Thrombotic thrombocytopenic purpura (TTP) is characterized by life-threatening destruction of intravascular erythrocytes and platelets, by mechanisms that remain poorly understood. In October 4 Nature ...

There is the Addams Family. And then there is the ADAMTS family. While one is mindless entertainment, the latter may prove to be a new genetic avenue for designing ovarian cancer treatment, scientists ...