2026年1月12日，《Aging Cell》在线发表了一项由牛津大学波塔林研究所完成的里程碑式研究，首次揭示了 雷帕霉素（Rapamycin）通过增强DNA损伤修复能力延缓免疫衰老的分子机制 。这项研究不仅破解了 mTOR抑制剂 ...

衰老是一个多因素过程，受遗传、环境和代谢因素影响。营养感知失调和代谢功能障碍是衰老的标志，胰岛素/IGF-1信号的减少或代谢干预（如热量限制）可延长物种寿命。

首先，研究人员发现暴露于D-gal的HEI-OC1细胞中NAD水平显著降低。为评估D-gal诱导衰老细胞基因表达的变化，利用蛋白质组学检测暴露于D-gal的HEI-OC1细胞中的蛋白质表达，结果显示，D-gal诱导衰老模型中NMNAT1表达显著降低。

For some, January is a time for resolutions, with the goal often tied to being fitter and healthier. And increasingly this ...

For decades, aging has looked like a one-way street, a slow accumulation of damage written into our cells. Now a wave of ...

As people age, their immune systems deteriorate. This makes them more susceptible to infections and can mean that vaccines ...

As people grow older, their immune systems do not simply slow down, they often become locked into a simmering, self-perpetuating state of inflammation. Emerging work now suggests that aging immune ...

During vaccination, the immune system is purposefully exposed to weakened, inactivated, or a component of pathogens so that the body can recognize their molecular structures in the future and mount a ...

A combination of high-resolution imaging and machine learning, also known as artificial intelligence (AI), can track cells damaged from injury, aging, or disease, and that no longer grow and reproduce ...

Researchers from University of California San Diego Sanford Stem Cell Institute have discovered that spaceflight accelerates the aging of human hematopoietic stem and progenitor cells (HSPCs), which ...