We describe a statistical analysis methodology designed to minimize the impact of off-target activities upon large-scale RNA interference (RNAi) screens in mammalian cells. Application of this ...

A milestone report proposes a new technique for modeling molecular life with computers. The advance promises new insights into the fundamental biology of a cell, as well as faster and more precise ...

The classical approach to probability theory requires that estimates for probability distributions be based on empirical data. However, in many practical cases, the available data may not be available ...