泛血管疾病由慢性低度炎症和免疫失调驱动，补体C3作为多途径整合节点，调控内皮激活、平滑肌细胞重塑及免疫细胞浸润。C3 ...

Serum complement proteins comprise an important system that is responsible for several innate and adaptive immune defence mechanisms. There were three well-described pathways known to lead to the ...

PHILADELPHIA – How molecules of the oldest branch of the human immune system have interconnected has remained a mystery. Now, two new structures, both involving a central component of an enzyme ...

Apellis Pharmaceuticals Inc. has identified C3 convertase inhibitors reported to be useful for the treatment of cancer, obesity, infections, neurological disorders, autoimmune and inflammatory ...

The complement system is a part of the immune system that enhances (complements) the ability of antibodies and phagocytic cells to clear microbes and damaged cells from an organism, promotes ...