T cells dynamically adapt to signals in the TME, transitioning between effector, exhausted, and regulatory states. Cellular interactions, metabolic stress, and physical barriers (e.g., ECM) shape ...

UCLA scientists have developed advanced miniature 3D tumor organoid models that make it possible to study glioblastoma tumors ...

EMBL scientists discovered self-sustaining inflammatory circuits in the bone marrow stem cell microenvironment that precede blood cancers. The illustration shows cancer cells against a background of ...

Magnetic nanoparticles engineered T cells inside living mice and guided them into solid tumors, achieving over 90% tumor ...

Cancer neuroimmunology integrates the study of the nervous system's influence on tumor immunity, highlighting an intricate ...

As people age, their immune function gradually declines, coinciding with increased cancer rates. However, the precise reasons behind age-related dysfunction of CD8+ T cells in cancer remain unclear.

Combination therapies represent a promising frontier in cancer treatment, addressing the critical need to enhance efficacy ...