A recent integrative analysis of single-cell sequencing and single-cell spatial mapping of lymph node metastasis in breast cancer reveals novel mechanisms of the metabolic-immune interaction that ...

该研究发现了一种化疗诱导的PTGER3+ CAF亚群，其脂质氧化增加。这些CAFs分泌11-HETE，通过抑制PTEN相关信号改善CD8+ T细胞功能。这种CAF亚群的丰富与改善的治疗反应相关，揭示了支持抗肿瘤免疫的基质机制。 肿瘤微环境 ...

FAS, fatty acid synthase; FATP, fatty acid transporter protein; GPCR, G protein-coupled receptor; LPC, lysophosphatidylcholine; LXR, liver X receptor; PPARγ, peroxisome proliferator-activated receptor ...

Roswell Park Comprehensive Cancer Center postdoctoral researcher Catherine Rono studies how metabolic stress in myeloid cells ...

Tumor metabolomics is an emerging field focused on understanding the metabolic alterations that occur in tumor cells and their surrounding microenvironment. These changes are essential to support the ...

Researchers identified invasive early disseminated cancer cells and immunosuppressive macrophage signaling that promote ...

The study of metabolism within the tumour microenvironment (TME) is a rapidly evolving field that holds significant implications for understanding cancer pathogenesis and developing novel therapeutic ...

Head and neck cancer remains a major global health challenge, ranking among the six most common cancers worldwide and claiming hundreds of thousands of lives each year. A growing body of evidence now ...

Breast cancer cells (green) invading through a layer of fibroblasts (red) (photo: Luke Henry / the ICR, 2009) Cells from the most common form of breast cancer can reprogram their metabolism to help ...

Solid tumors often provide a challenging environment for the T cells of our immune system. By reprogramming the metabolism of T cells, scientists at the VIB-KU Leuven Center for Cancer Biology and ...