Since international guidelines were finalized nearly a decade ago, the pharmaceutical industry has spent hundreds of millions of dollars testing drug candidates preclinically and in humans using ...

Future Cardiol. 2012;8(4):647-670. Although redox-induced damage is likely involved in anthracycline-induced cardiotoxicity, some evidence suggests that it is not the only mechanism at play. Several ...

Assessment of Cardiac Dysfunction in a Randomized Trial Comparing Doxorubicin and Cyclophosphamide Followed by Paclitaxel, With or Without Trastuzumab As Adjuvant Therapy in Node-Positive, Human ...

Primary cultures of spontaneously beating myocardial cells isolated from neonatal rat hearts were used to screen the cardiotoxic effects of Jamesoni's mamba (Dendroaspis jamesoni) venom and components ...

Scholastic Achievements of Childhood Leukemia Patients: A Nationwide, Register-Based Study The design and efficacy of the major adjuvant trastuzumab trials was assessed, including the National ...

Black patients with cancer are significantly more likely to experience cardiotoxicity and congestive heart failure related to chemotherapy than White cancer patients are, a research review indicates. ...

A new meta-analysis published in OMICS: A Journal of Integrative Biology helps shed light on how changes in mitochondria-related gene expression may cause the cardiotoxicity associated with the cancer ...

We announce the publication of a new research paper titled 'Dual transcriptomic and molecular machine learning predicts all major clinical forms of drug cardiotoxicity' in Frontiers in Pharmacology.

Cardiotoxicity underlies a third of failures in regulatory clearance, making it among the most significant hurdles in developing new drugs. 1 axoCells human iPSC-derived ventricular cardiomyocytes ...

Radiation and chemotherapy for Hodgkin's lymphoma can lead to late-onset cardiotoxicity, including coronary artery disease. Self-advocacy and detailed medical history are crucial for timely diagnosis ...