Researchers at The Institute of Cancer Research, London identified the CIP2A–TOPBP1 complex as a master regulator of DNA repair during mitosis, coordinating backup pathways that protect chromosomes ...

Non-coding DNA is essential for both humans and trypanosomes, despite the large evolutionary divergence between these two species.

Researchers at the Centre for Genomic Regulation (CRG) reveal that metabolic enzymes known for their roles in energy production and nucleotide synthesis are taking on unexpected "second jobs" within ...

Surprisingly, forcing an acceleration of replication forks led to miscoordination between genome replication completion and cell cycle progression. Dr. Tsubouchi concludes, "We propose that slow ...

Our DNA is constantly being packed and unpacked. And there is a good reason for this: depending on its packing state, it performs different functions in the cell nucleus. For most of its life – this ...

A Northwestern Medicine study has revealed a previously unknown connection between two fundamental cellular processes, ...

A time-delay circuit enables precise control over the division of synthetic DNA droplets, which mimic biological Liquid-Liquid Phase Separation (LLPS) droplets found in cells. By utilizing a ...

Many cellular functions in the human body are controlled by biological droplets called Liquid-Liquid Phase Separation (LLPS) droplets. These droplets, made of soft biological materials, exist inside ...

Among the many marvels of life is the cell's ability to divide and thus enable organisms to grow and renew themselves. For this, the cell must duplicate its DNA—its genome—and segregate it equally ...

Danish researchers believe that everyone should monitor their blood folate levels. They argue that a deficiency in folic acid ...