We used a 5-L B-DCU bioreactor (Sartorius, Göttingen, Germany) with a working volume of 2 L. The setup, technical equipment and control loops are summarized in Fig. 1. The culture broth was stirred in ...

Continued process verification (CPV) is the third stage of the product lifecycle of any medicine either within the small or large molecule arena. The CPV is the subsequent step to process design ...

Researchers at the University of Liège (BE) have designed a high-performance, open-access continuous flow process to safely produce key antibacterial drugs from bio-based furfural. The results of the ...

DIANT is a startup co-founded by Antonio Costa, Ph.D. and Diane Burgess, Ph.D. In 2020, DIANT licensed their core manufacturing technology from UConn and was granted a patent on the technology earlier ...

Continuous flow techniques have become important tools for molecular synthesis, both in academia and across the fine chemicals industry. The success of these methods has been in part due to their ...

A photo of technicians working in front of a process train. Novartis's continuous manufacturing center in Basel, Switzerland, replicates an end-to-end manufacturing process developed at the ...

Using continuous processing instead of batch-based processing provides therapeutic manufacturers with a number of advantages. For example, the continuous approach can ...

Biopharma 4.0 is often presented as an all-or-nothing proposition, when in fact its components have all been around for a while and have independent value. It appears the major challenge will be ...

Standard methods for additive manufacturing, also known as 3D printing, have major drawbacks with regards to process speed and mechanical strength of the finished product. Standard commercial ...

The breakthrough positions the specialty chemicals manufacturer at the forefront of advanced fluorination technologies, ...

A new study demonstrates the first cost-effective method for producing cultivated meat. The study shows that continuous manufacturing addresses the key challenges of scalability and cost, potentially ...