Millimetre-sized single crystals of covalent organic frameworks have been constructed by taking advantage of a reversible dimerization reaction of nitroso groups. Scientists and non-scientists alike ...

Chemical probes that form a covalent bond with a protein target often show enhanced selectivity, potency and utility for biological studies. Despite these advantages, protein-reactive compounds are ...

There are three types of bonds in chemistry: ionic, covalent, and metallic bonds. In this article, we will look at the differences between ionic and covalent bonds. Chemical bonding is the force of ...

When most small-molecule drugs meet a protein target, they nestle close to their intended. But the flirtatious relationship between drug and target is often fleeting, with the drug repeatedly drifting ...

Each atom then has a complete outer shell of electrons. The slideshow shows how a covalent bond forms between a hydrogen atom and a chlorine atom, making hydrogen chloride. A simple molecule contains ...

Silica has a giant covalent structure containing silicon atoms (grey) and oxygen atoms (red) Learn more on properties of giant covalent compounds in this podcast. Listen to the full series on BBC ...

Prior to 2000, many drugs that formed a covalent bond with targets did so non-selectively, which often led to undesired side effects when compared to non-covalent drugs. This led to the belief that ...