Chemical probes that form a covalent bond with a protein target often show enhanced selectivity, potency and utility for biological studies. Despite these advantages, protein-reactive compounds are ...

Naturally occurring peptides and proteins often use dynamic disulfide bonds to impart defined tertiary/quaternary structures for the formation of binding pockets with uniform size and function.

The latest short science news items from C&EN. Open an introductory chemistry textbook. What is a covalent bond? A covalent bond occurs when atoms share electrons in a molecule. What is a hydrogen ...

When most small-molecule drugs meet a protein target, they nestle close to their intended. But the flirtatious relationship between drug and target is often fleeting, with the drug repeatedly drifting ...

Covalent bonds are strong and require substantial amounts of energy to break. Covalent bond: a shared pair of electrons. Molecule: two or more atoms covalently bonded together.

Each atom then has a complete outer shell of electrons. The slideshow shows how a covalent bond forms between a hydrogen atom and a chlorine atom, making hydrogen chloride. A simple molecule contains ...