本研究针对真核生物同源重组中RAD51介导的链交换机制不明确的问题，通过冷冻电镜技术捕获了五个关键中间体结构，结合分子动力学模拟，揭示了由N端结构域(NTD)引导的DNA逐步弯曲、L2环插入促进链分离以及S2位点稳定产物的空间协同机制，为理解DNA修复提供了 ...

Scientists from the Kavli Institute of Delft University of Technology and the IMP Vienna Biocenter discovered a new property of the molecular motors that shape our chromosomes. While six years ago ...

Scientists have discovered a new property of the molecular motors that shape our chromosomes. While six years ago they found that these so-called SMC motor proteins make long loops in our DNA, they ...

In certain toy racecar tracks, sneaky players can flip a switch, trapping their opponents' vehicles in a loop of track. Cells employ a less subtle approach: they change the track's layout. In a study ...

Not all DNA looks like the familiar double helix. Sometimes, parts of our genetic code fold into unusual shapes under certain conditions. One such structure known as a G-quadruplex (G4) looks like a ...