复制叉停滞后的修复通路如何“排班”一直成谜。UC Davis团队锁定酵母Rad51，发现E135D、K305N两突变大幅削弱其对dsDNA的亲和力，却保留ssDNA结合与D-loop活性，导致MMS诱导的 fork 保护失效、突变率飙升，并迫使细胞转向TLS与Rad51非依赖的模板转换。该工作首次直接证实Rad51-dsDNA相互作用是调控post-replication ...

Scientists from Delft, Vienna, and Lausanne discovered that the protein machines that shape our DNA can switch direction. Until now, researchers believed that these so-called SMC motors that make ...

Scientists from the Kavli Institute of Delft University of Technology and the IMP Vienna Biocenter discovered a new property of the molecular motors that shape our chromosomes. While six years ago ...

One of the most detailed 3D maps of how the human chromosomes are organized and folded within a cell's nucleus is published in Nature. Chromosomes are thread-like structures that carry a cell's ...

Not all DNA looks like the familiar double helix. Sometimes, parts of our genetic code fold into unusual shapes under certain conditions. One such structure known as a G-quadruplex (G4) looks like a ...

Scientists have discovered a new property of the molecular motors that shape our chromosomes. While six years ago they found that these so-called SMC motor proteins make long loops in our DNA, they ...

Among the many marvels of life is the cell's ability to divide and thus enable organisms to grow and renew themselves. For this, the cell must duplicate its DNA – its genome – and segregate it equally ...

The illustration shows DNA being folded into a loop by an SMC motor called cohesin (in purple/blue). The purple part of the motor (with a red/green label) is the protein subunit NIPBL, which acts as a ...

Changes in genes have been linked to the development of different diseases for a while. However, it's not exactly clear what ...