The inhibition of HIV-1’s replicative machinery remains a cornerstone in the battle against AIDS. Central to this approach are inhibitors targeting reverse transcriptase (RT) and integrase. Reverse ...

Background. Factors promoting the emergence of human immunodeficiency virus type 1 (HIV-1) reverse transcriptase (RT) connection domain mutations and their effect on antiretroviral therapy (ART) are ...

HIV-1 reverse transcriptase inhibitors remain a cornerstone of antiretroviral therapy, targeting the enzyme responsible for converting viral RNA into DNA. This class of drugs, particularly nucleoside ...

A mutation in a little-studied structural region of the AIDS virus can cause resistance to several HIV drugs, according to a study. Several mutations in reverse transcriptase (RT), the viral enzyme ...

The crystal structure of a human endogenous reverse transcriptase has similarities to HIV reverse transcriptase, a well-known tractable drug target, which will help design drugs to treat cancer and ...

Proceedings of the National Academy of Sciences of the United States of America, Vol. 116, No. 36 (September 3, 2019), pp. 17809-17816 (8 pages) HIV type I (HIV-1) reverse transcriptase (RT) catalyzes ...

REDWOOD CITY, Calif., Dec. 15, 2021 (GLOBE NEWSWIRE) -- Codexis, Inc. (NASDAQ: CDXS), a leading enzyme engineering company enabling the promise of synthetic biology, today announced the launch of its ...

Thermo Fisher Scientific Inc. TMO recently launched its Applied Biosystems HIV-1 Genotyping Kit with Integrase. This research only evaluates positive human immunodeficiency virus (HIV) samples to ...

The availability of an increasing number of antiretroviral agents and the rapid evolution of new information about them have introduced substantial complexity into the treatment regimens of persons ...

The crystal structure of a human endogenous reverse transcriptase has similarities to HIV reverse transcriptase, a well-known tractable drug target, which will help design drugs to treat cancer and ...

Phase I and pharmacokinetic study of an oral platinum complex given daily for 5 days in patients with cancer. The specificity of RT-PCR assays with primers specific for various tumor-associated and ...

Protein multiplex sandwich immunoassay: A reliable and objective method for complete molecular characterization of breast cancer from core needle biopsies ...