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综述:DNA聚合酶α-引物酶(polα-primase)复合物的激酶调控:基于十年 ...
这篇综述系统阐述了激酶介导的磷酸化调控网络对DNA聚合酶α-引物酶(polα-primase)复合物的精细调控机制,重点解析了催化亚基POLA1的磷酸化位点特征及其与POLA2、PRIM1、PRIM2亚基的协同调控模式。通过整合质谱磷酸化蛋白质组学数据,揭示了CDK、MAPK等激酶家族 ...
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