The hypothalamus is a small but critical region at the base of the brain that controls the autonomic nervous system, regulates body temperature, signals hunger and thirst, exerts hormonal control over ...

FDA approval establishes setmelanotide as the first labeled option for acquired hypothalamic obesity, addressing a population estimated at ~10,000 in the US and characterized by severe hyperphagia.

Hypothalamic obesity (HyOb) develops when damage to the hypothalamus — from brain tumors, traumatic brain injury, radiation therapy, or stroke — disrupts how your body regulates appetite and ...