The targeting of somatic hypermutation (SHM) occurs at two distinct levels. 'Global' targeting refers to the fact that rearranged immunoglobulin variable regions are the primary substrate for SHM. By ...

Immunoglobulin class-switch recombination (CSR) is a B-cell specific DNA-rearrangement reaction that exchanges the expressed Ig heavy-chain constant-region gene (C H) from Cμ to another downstream C H ...