Novel Approach to Achieving Consistent Results with the Limulus Amebocyte Lysate Test The standard tool for screening endotoxins—highly toxic, heat-stable lipopolysaccharides that constitute the outer ...

The World Health Organization (WHO) has published its new 2025 Guidelines on the replacement or removal of animal tests for the quality control of biological products.

Bacteria can be found everywhere—even sometimes in clean rooms. That’s a problem for manufacturers of drugs and medical devices that are injected or implanted. Even if manufacturers can remove the ...

Endotoxin refers to a component of the outer cell membrane of Gram-negative bacteria called lipopolysaccharide (LPS). LPS is the biologically active portion of naturally occurring endotoxin complexes.

A chemical compound found in the blood of horseshoe crabs is widely used in the biomedical community to test for the presence of bacterial exposure or infection. This limulus amebocyte lysate (LAL) ...