Scientists have discovered a new property of the molecular motors that shape our chromosomes. While six years ago they found that these so-called SMC motor proteins make long loops in our DNA, they ...

Scientists from the Kavli Institute of Delft University of Technology and the IMP Vienna Biocenter discovered a new property of the molecular motors that shape our chromosomes. While six years ago ...

Not all DNA looks like the familiar double helix. Sometimes, parts of our genetic code fold into unusual shapes under certain conditions. One such structure known as a G-quadruplex (G4) looks like a ...

Surprisingly, forcing an acceleration of replication forks led to miscoordination between genome replication completion and cell cycle progression. Dr. Tsubouchi concludes, "We propose that slow ...

Among the many marvels of life is the cell's ability to divide and thus enable organisms to grow and renew themselves. For this, the cell must duplicate its DNA—its genome—and segregate it equally ...

A team of researchers at VCU Massey Comprehensive Cancer Center has identified a new pathway through which mutations in the tumor suppressor p53 gene—found very frequently in human tumors—hijack DNA ...

The illustration shows DNA being folded into a loop by an SMC motor called cohesin (in purple/blue). The purple part of the motor (with a red/green label) is the protein subunit NIPBL, which acts as a ...

Scientists from Delft, Vienna, and Lausanne discovered that the protein machines that shape our DNA can switch direction. Until now, researchers believed that these so-called SMC motors that make ...

This transcript has been edited for clarity. For more episodes, download the Medscape app or subscribe to the podcast on Apple Podcasts, Spotify, or your preferred podcast provider. Dr Liu is a ...