These discoveries suggest that certain cancer treatments may be useful therapeutically for Alzheimer’s disease.

Researchers had previously discovered a population of immune cells within the brain that can act as accelerators and brakes ...

Glioblastoma, the most common and most aggressive brain tumor type in adults, remains difficult to treat because it can infiltrate surrounding brain tissue and spread far beyond the main tumor.

As the body ages, cells naturally accumulate dozens of genetic mutations each year. New research from Boston Children's ...

A rare but potent genetic mutation that alters a protein in the brain’s immune cells, known as microglia, can give people as much as a three-fold greater risk of developing Alzheimer’s disease. A new ...

A new study finds that microglia with mutant TREM2 protein reduce brain circuit connections, promote inflammation and contribute to Alzheimer's pathology in other ways. A rare but potent genetic ...

Using Alzheimer’s mouse models, human cells, and human brain tissue, the researchers demonstrated that lowering PU.1 promotes the expression of lymphoid immunoregulatory receptor proteins on microglia ...

Microglia in the brain’s parenchyma arise from macrophage progenitors in the embryonic yolk sac (Ginhoux et al., 2010), and are thought to self-renew locally during a mammal’s lifespan, without ...

During development, there are known sex-related differences in how microglia function. But into adulthood, there was thought to be less variation in how they behave. Microglia maintain neuronal ...

A collision happens. Someone is hurt, a head injury, a concussion. Just as the first responders arrive to help the person, inside the brain, another "crew" of responders is busy clearing debris and ...