Cancer biology increasingly recognizes that cancer stem cells (CSCs) represent a critical subpopulation within tumors, marked by their self-renewal, ...

Scientists at the University of Pittsburgh, together with colleagues at the University of Pittsburgh School of Medicine and University of Pittsburgh Cancer Institute, have identified how a long ...

Epigenetics is the study of heritable changes in gene expression that do not involve alterations to the underlying DNA sequence. These changes can significantly impact gene activity and cellular ...

Our genes contain all the instructions our body needs to function, but their expression must be finely regulated to guarantee that each cell performs its role optimally. This is where DNA and RNA ...

Back in 1942, the term epigenetics was introduced by Conrad Waddington to present a picture of cell development, one in which cells descended a hillside and followed diverging valley paths before ...

At the onset of diabetic cardiomyopathy, Trdn-as expression increases, which regulates the methylation of Casq2 mRNA mediated by METTL14, thus increasing the stability and expression of Casq2 mRNA.

Scientists have identified an RNA-based sperm aging clock driven by rsRNA length changes, which may help assess paternal reproductive risk and offspring health.

This article explains how diet creates sustained epigenetic changes that affect long-term health, disease risk, aging, and ...