Upregulation of FLT3 with internal tandem repeats (FLT3-ITD) occurs in approximately one quarter of patients with de novo acute myeloid leukemia (AML). Patients with FLT3-ITD often have more ...

The Notch signaling pathway plays a pivotal role in determining cell fate, especially in the development and function of T cells. But mimicking this highly mechanical, contact-dependent pathway in the ...

Delta-like ligand-3 (DLL3) is a single-pass, type I transmembrane protein that inhibits the Notch signaling pathway. A highly conserved intercellular signaling pathway, the Notch signaling pathway ...