In this study, we hypothesize that between the HMM and NHMM myeloma subtypes, distinct TrF pathways dysregulate converging cancer pathways. This hypothesis motivates us to develop a TrF-pathway ...

It is widely assumed that mitotic cyclins are rapidly degraded during anaphase, leading to the inactivation of the cell cycle-dependent protein kinase Cdc2 and allowing exit from mitosis. The ...

The E2F family of transcriptional factors is important in cell-cycle regulation by controlling the expression of genes that mediate cell-cycle progression, DNA replication and DNA synthesis (Trimarchi ...

This is a preview. Log in through your library . Abstract Clp ATPases are ring-shaped AAA+ motors in the degradation pathway that perform critical actions of unfolding and translocating substrate ...

Biological indicators of response and resistance to PARP inhibition in BRCA wild-type breast cancer. This is an ASCO Meeting Abstract from the 2015 Breast Cancer Symposium. This abstract does not ...