Primases are essential RNA polymerases required for the initiation of DNA replication, lagging strand synthesis and replication restart. Many aspects of primase function remain unclear, including how ...

The cellular replicative DNA polymerases cannot initiate DNA synthesis without a priming 3′ OH. During DNA replication, this is supplied in the context of a short RNA primer molecule synthesized by ...

这篇综述系统阐述了激酶介导的磷酸化调控网络对DNA聚合酶α-引物酶（polα-primase）复合物的精细调控机制，重点解析了催化亚基POLA1的磷酸化位点特征及其与POLA2、PRIM1、PRIM2亚基的协同调控模式。通过整合质谱磷酸化蛋白质组学数据，揭示了CDK、MAPK等激酶家族 ...

The length of telomeres that protect the ends of our chromosomes should be tightly regulated. Those that are too long predispose to cancer, and those that are too short lose their protective ability, ...