The formation of amyloid fibrils and the aggregation of misfolded proteins are central to the pathology of Alzheimer’s disease. At the molecular level, normal proteins adopt aberrant conformations ...

Yeast prions are increasingly recognised as pivotal agents in non-Mendelian inheritance, whereby protein conformations rather than nucleic acids dictate heritable traits. In Saccharomyces cerevisiae ...

Tau protein aggregation is a shared feature in over 20 neurodegenerative diseases (collectively referred to as "tauopathies"). New research led by Boston Children's Hospital challenges the current ...

Researchers headed by a team at the Centre for Genomic Regulation, Barcelona Institute of Science and Technology and at the Wellcome Sanger Institute have developed an AI tool that they say has made a ...

The factor that tips you over the edge from being at risk for a disease to actually developing the disease is not always clear. Now, researchers from Japan report one factor that triggers problematic ...

Researchers have developed a 'self-driving' microscope that can predict the onset of misfolded protein aggregation - a hallmark of neurodegenerative disease - as well as analyze the biomechanical ...

The accumulation of misfolded proteins in the brain is central to the progression of neurodegenerative diseases like Huntington’s, Alzheimer’s and Parkinson’s. But to the human eye, proteins that are ...

Back when James Parkinson first described the disorder now known as Parkinson’s disease, he noticed that severe constipation can be a prelude to the signature tremors. In the 208 years since then, ...

Micro- and nanoplastics are increasingly detected in human tissues, including the brain, and experimental evidence suggests ...

The fluorescence microscopy images show the nuclei of cultured human cells. On the left, the protein TDP‑43 (green) is seen distributed within the cell nucleus along with nuclear bodies (red), which ...

Raghu R. Chivukula, MD, Ph.D., a physician-investigator in the Departments of Medicine & Surgery and the Center for Genomic Medicine at Massachusetts General Hospital and Harvard Medical School, is ...

An AI tool has made a step forward in translating the language proteins use to dictate whether they form sticky clumps similar to those linked to Alzheimer's disease and around fifty other types of ...