Bacillus subtilis has emerged as a pre‐eminent model organism for the study and application of protein expression and secretion, owing to its robust secretory pathways and genetic tractability. Its ...

Oxidative stress induced by 6-OHDA stimulates autophagy flux, which enhances STX17-mediated autolysosome formation, leading to the degradation of autophagosomal contents. However, in response to ...

Cells have sophisticated methods of sensing stimuli and communicating with nearby cells in response to these stimuli. For example, macrophages can sense environmental stimuli—tissue damage, foreign ...

Bacterial interaction with plants and animals, symbiotic or pathogenic, involves the transfer to host cells and tissues of a range of bacterial proteins whose biochemical activities are key to ...

Intracellular protein trafficking and secretion of proteins into the extracellular environment are sequential and tightly regulated processes in eukaryotic cells. Conventionally, proteins that are ...

Kezar’s drug discovery platform of protein secretion pathway inhibitors is a novel approach with broad application. The protein secretion pathway is a highly conserved and ubiquitously functioning ...

Inside the race to turn one of cell biology’s least understood processes into a new foundation for drug development and ...

Seed round co-led by Elaia, Pfizer Ventures and Bpifrance Machine-learning platform enables signal peptide-informed discovery ...