RNA sequencing has emerged as a powerful supplement to DNA sequencing for Mendelian disease diagnosis, but clinical translation of diagnostic RNA-seq has not been widely achieved. Researchers at ...

近日，研究团队在国际知名期刊《信号转导与靶向治疗》（Signal Transduction and Targeted Therapy，IF=52.7）发表了一项重磅研究：首次系统性地揭示了关键信号分子MAPK14（又称p38α）在腹主动脉瘤（AAA）形成中的核心作用机制。该研究通过整合单细胞多组学、表观遗传学及深入的分子生物学验证，发现MAPK14通过操控一个关键的转录调控网络，驱动血管平滑肌细胞 ...

RNA sequencing (RNA-seq) is a powerful tool in diagnosing Mendelian disorders, but the optimized sequencing depth for this technology has not yet been determined. In a new study published in the ...

According to research from a team at the University of Utah Health and the University of Nevada, Reno School of Medicine, ...

Researchers from the Faculty of Engineering at The University of Hong Kong (HKU) have developed two innovative deep-learning algorithms, ClairS-TO and Clair3-RNA, that significantly advance genetic ...

Scientists can peer into cells to get a limited view of their activity using microscopes and other tools. However, cells and ...

Adjuvant abemaciclib outcomes in routine clinical practice (experience of several Moscow centers). This is an ASCO Meeting Abstract from the 2025 ASCO Annual Meeting I. This abstract does not include ...

2026年1月12日，牛津纳米孔技术公司（Oxford Nanopore Technologies）首席执行官Gordon Sanghera在第44届摩根大通医疗健康年会（J.P. Morgan Healthcare Conference, JPM ...

The landscape of next-generation sequencing (NGS) continues to be defined by astonishing technological progress. We continue to witness sequencer throughput expansion with systems like the Illumina ...