RNA molecules exhibit an astonishing diversity in structure, which is integral to their myriad cellular functions ranging from gene regulation to catalysis. Advances in experimental techniques and ...

The field of RNA structure prediction and modeling has undergone substantial transformation in recent years, reflecting a confluence of innovative computational strategies and expanding experimental ...

RVPSD共收录154,716个RNA病毒蛋白结构，覆盖5,263种RNA病毒和149个病毒科，是目前最大的RNA病毒蛋白结构数据库。所有蛋白结构均基于AlphaFold2预测获得，其中84.9%的结构具有较高结构置信度（pLDDT＞70）。数据库在分类和功能注释层面均具有广泛覆盖，既包括黄病毒、小RNA病毒、冠状病毒等公共卫生高度关注的病毒科，也涵盖大量研究较少的新发现或未充分注释表征的RNA病 ...

RIKEN researchers have discovered how an enzyme modifies gene expression by targeting certain stretches of messenger RNA ...

Researchers show how LGP2 binds viral RNA ends, moves along the strand, and helps MDA5 form filaments that amplify antiviral signaling. The findings clarify an early defense step and may inform ...

A proposed function of TADs is to contribute to gene regulation by promoting chromatin interactions within a TAD and by suppressing interactions between TADs. Here, we directly probe the ...

New research shows that lipid nanoparticles used in mRNA vaccines may deliver RNA more effectively when their structure is disorganised.

Studying a trio of non-coding RNA molecules produced abundantly in bacterial cells, a SLAC/Stanford-led research team discovered extravagant, multistrand complexes made entirely of RNA—structures they ...

When RNA molecules are synthesized by cells — a critical process in the creation of proteins and other cellular functions — they typically undergo a series of “folding” events that determine their ...

Neurons have a "hibernation mode." Scientists discover how brain cells use RNA tentacles to lock their protein factories together to survive when energy is low.

A strand of RNA just 45 nucleotides long has been discovered to perform two key reactions required for self-replication. The ...

With big pharma signalling interest in novel RNA-targeted approaches, the term “druggable” is being redefined as technology advances.