Glutamate receptors, including AMPA and NMDA subtypes, are pivotal mediators of excitatory transmission and plasticity across the mammalian central nervous system. Their regulation, which involves ...

A holistic inquiry into how toxic tau impacts synapses provides a new take on the processes that lead to neuronal dysfunction ...

Cognitive tasks, such as learning and memory, require rapid changes to proteins at synapses, such as protein synthesis, degradation, and trafficking. How protein post-translational modifications ...

A study mapped genes linked to schizophrenia and uncovered a mechanism that disrupts synaptic plasticity in affected individuals. The researchers showed the role of three proteins in mediating the ...

Scientists disclose how mitochondria control tissue rejuvenation and synaptic plasticity in the adult mouse brain. Nerve cells (neurons) are amongst the most complex cell types in our body. They ...

As animals experience new things, the connections between neurons, called synapses, strengthen or weaken in response to events and the activity they cause in the brain. Neuroscientists believe that ...

Alzheimer's disease (AD) is a debilitating neurodegenerative condition that affects a significant proportion of older people worldwide. Synapses are points of communication between neural cells that ...

Li’s study, “TIAM1-mediated synaptic plasticity underlies comorbid depression-like and ketamine antidepressant-like actions in chronic pain," was recently published in The Journal of Clinical ...

Alzheimer’s disease (AD) remains one of the most pressing neurodegenerative disorders worldwide, characterized by progressive memory loss, synaptic ...

This mitochondrial process supports the brain cells essential to learning, memory and social recognition. We know that mitochondria are the powerhouses of the cell, but what role do they play in ...