The complement system is a crucial part of innate immune defenses against invading pathogens. The blood-meal of the tick Rhipicephalus pulchellus lasts for days, and the tick must therefore rely on ...

Efb-C通过增强FHR2与C3b的相互作用抑制补体下游反应，但不影响C3转换酶形成。研究显示Efb-C与C3b结合后，FHR2的2-4结构域与C3d的结合能力显著提升，且这种效应在完整FHR2而非截短片段中体现。尽管Efb-C单独可阻断C3前体酶形成，但与FHR2协同能更有效抑制补体C5激活后 ...

Global understanding of complement has shifted and developed since the 21st century: from our idea of a blood-based antibiotic system to a global regulator of immunity and tissue homeostasis. Recent ...

Left untreated, PNH could cause death in about half of patients within 10 years of diagnosis. The primary cause of PNH-related mortality is thromboembolic events. A host of anti-complement strategies, ...

AJMC ®: How has treatment of complement-driven diseases changed since 2007, when the first complement inhibitor, eculizumab, was approved? SMITH: The development of eculizumab followed our ...