Efb-C通过增强FHR2与C3b的相互作用抑制补体下游反应，但不影响C3转换酶形成。研究显示Efb-C与C3b结合后，FHR2的2-4结构域与C3d的结合能力显著提升，且这种效应在完整FHR2而非截短片段中体现。尽管Efb-C单独可阻断C3前体酶形成，但与FHR2协同能更有效抑制补体C5激活后 ...
Following 2 doses of OMS906, all patients achieved an increase in hemoglobin of ³ 4.0 g/dL, with a mean hemoglobin change from baseline of 4.75 g/dL (p < 0.001) Following 3 doses of OMS906, mean ...
Opportunities in the C5 inhibitors market include developing next-gen biosimilars and biosuperiors to improve administration frequency and expand treatment indications for diseases like aHUS, SCD, MG, ...
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