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Small RNA CLEAR-CLIP-seq:精准鉴定small RNA 靶点的研究利器
small RNA(包括 miRNA、tRF&tiRNA、sdRNA 等)是重要的小型非编码RNA分子,通过序列互补配对引导AGO蛋白结合mRNA的3'-UTR或CDS区域,从而介导mRNA降解或翻译抑制。 small RNA 靶点研究的核心难题 small RNA 在发育、代谢、肿瘤、免疫等多种生命过程中发挥关键调控作用,但 ...
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