Retinitis pigmentosa (RP) is a genetic eye disorder affecting around one in 5,000 people worldwide. It typically begins with ...

总的来说，这项研究提供了大脑皮层中大量的 lncRNA 和 circRNA 及其相应的顺式表达数量性状基因座（cis-eQTL），这有助于更深入地理解大脑皮层中基因表达的遗传调控，并弥合大脑相关疾病遗传关联与其病理生理机制之间的差距。

本综述系统探讨了非编码RNA（ncRNA），特别是微小RNA（miRNA）和长链非编码RNA（lncRNA）在阿尔茨海默病（AD）中的关键作用。文章深入阐述了miRNA（如miR-124, miR-107）和lncRNA（如NEAT1, BACE1-AS）如何通过调控Aβ代谢、Tau蛋白磷酸化、神经炎症及氧化应激等核心病理过程 ...

The function of non-coding RNA in the cell has long been a mystery to researchers. Unlike coding RNA, non-coding RNA does not produce proteins -- yet it exists in large quantities. A research team has ...

全基因组关联研究（GWAS）已确定了大量与人类复杂性状相关的遗传变异。尽管有了这些发现，但要破译全基因组关联研究信号背后的分子机制仍是一项艰巨挑战。 大多数与性状相关的变异位于非编码区，这表明它们可能通过基因调控来影响性状。数十年来的 ...

本刊推荐：为解决非编码RNA(ncRNA)通过RNA:DNA:DNA三链体(triplex)介导基因调控的预测工具复杂性问题，研究人员开发了TripLexicon ...

The function of non-coding RNA in the cell has long been a mystery to researchers. Unlike coding RNA, non-coding RNA does not produce proteins – yet it exists in large quantities. A research team from ...

Although evolution awarded us with appendages and complex sensory systems, the human body, much like a worm, is simply a large tube transporting food from one end to the other. It is hard to imagine ...

Cancer is most treatable in its early stages, so finding innovative and non-invasive methods to diagnose cancer early on is crucial for fighting the disease. Liquid biopsies, which require just a ...

Researchers disagree on the number of genes in the human genome, in part because what exactly a gene is can be difficult to determine. Upregulation of a specific microRNA in the brain lessened anxiety ...