A recent integrative analysis of single-cell sequencing and single-cell spatial mapping of lymph node metastasis in breast cancer reveals novel mechanisms of the metabolic-immune interaction that ...

该研究发现了一种化疗诱导的PTGER3+ CAF亚群，其脂质氧化增加。这些CAFs分泌11-HETE，通过抑制PTEN相关信号改善CD8+ T细胞功能。这种CAF亚群的丰富与改善的治疗反应相关，揭示了支持抗肿瘤免疫的基质机制。 肿瘤微环境 ...

Breast cancer development is not solely the result of cancer cells acting independently, it involves a dynamic and complex ecosystem composed of cancer cells, immune cells, fibroblasts, adipocytes, ...

Roswell Park Comprehensive Cancer Center postdoctoral researcher Catherine Rono studies how metabolic stress in myeloid cells ...

The study of metabolism within the tumour microenvironment (TME) is a rapidly evolving field that holds significant implications for understanding cancer pathogenesis and developing novel therapeutic ...

Researchers identified invasive early disseminated cancer cells and immunosuppressive macrophage signaling that promote ...

Head and neck cancer remains a major global health challenge, ranking among the six most common cancers worldwide and claiming hundreds of thousands of lives each year. A growing body of evidence now ...

Cancer research continues to evolve as scientists strive to unravel the complexities of tumor biology, molecular signaling, and metabolic adaptations.

PanMETAI combines AI and NMR metabolomics to detect early-stage pancreatic cancer from a blood sample, achieving 93 percent ...

Up to 80 percent of patients with cancer struggle with cachexia, often called wasting syndrome, which is a condition characterized by the inability to gain or maintain body weight. One of the reasons ...