Processive DNA polymerases that replicate chromosomes interact with a ring-shaped clamp that encircles DNA and slides along the duplex. All sliding clamps (Escherichia coli β-clamp, T4 bacteriophage ...

An essential fruit fly protein called CLAMP may help biologists answer the key question of how the same protein can manage to coordinate two completely different processes on distinct chromosomes in ...

PROVIDENCE, R.I. [Brown University] -- New research on a crucial protein in fruit flies provides a clear model for a fundamental question in biology that's significant for drug development in ...

During the process of bacterial DNA replication, DNA Polymerase, which catalyze the synthesis of DNA, plays an indispensable role. In order to keep DNA Polymerase III sliding along, a protein complex ...