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DAPI(4’,6-二脒基-2-苯基吲哚)作为新型淀粉样蛋白荧光标记物的 ...
淀粉样变性病的诊断长期依赖刚果红和硫磺素T染色,但操作复杂。为解决这一问题,研究人员探索了常见核染料DAPI(4’,6-Diamidino-2-Phenylindole)的淀粉样蛋白结合特性。通过比较DAPI与硫磺素T的立体化学特性,结合甲酸处理实验,发现DAPI能特异性识别β-折叠片 ...
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