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人类基因组中编码的HERV-K(HML-2)Rec蛋白的特性及其转录后功能
人类内源性逆转录病毒K(HERV-K)HML-2亚群的Rec蛋白功能多样性研究。通过分析55个类型2Provirus,发现9个Rec蛋白具有转录后调控活性,其中8个位于多态性整合位点。关键发现包括:12q14.1的Rec蛋白因N2H和E34del突变产生转主导阴性效应,仅E34缺失导致功能丧失;新 ...
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