Pulmonary arterial hypertension (PAH) involves progressive cellular and molecular change within the pulmonary vasculature, leading to increased vascular resistance. Current therapies targeting nitric ...

Abstract: Spatial transcriptomics (ST) enables the joint profiling of gene expression and spatial localization, offering new insights into tissue microenvironments and biological processes. However, ...

Advancements in spatial perturbation transcriptomics (SPT) have revolutionized our understanding of cellular behavior in native tissue contexts by integrating spatial and perturbation data. However, ...

aDepartment of Genetic and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA bDivision of Molecular Psychiatry, Department of Psychiatry, Yale University School of Medicine, ...

Abstract: Spatial transcriptomics has revolutionized the ability to investigate transcriptional patterns within tissue morphology. However, many ST clustering pipelines operate on a single preselected ...

The rapid development of spatial transcriptomics (ST) technologies has greatly advanced the understanding of gene expression, tissue architecture, cellular composition, and disease mechanisms within ...

Larotrectinib in Patients With Tumors With NTRK Fusions: Results From the NCI-MATCH ECOG-ACRIN Trial (EAY131) Subprotocol EAY131-Z1E Advancements in profiling technologies have deepened our ...