Brenner, S. 1959. The mechanism of gene action. CIBA Foundation Symposium on the Biochemistry of Human Genetics. Churchill, London, pp. 304–321.

Polygenic risk scores are commonly built using publicly available GWAS summary statistics from large scale biobanks or consortiums. With these summary statistics and some estimate of the linkage ...

这项工作说明，三维基因组并非DNA序列的被动载体，而是癌症演化中一个积极、动态的参与者。它像一只“无形的手”，通过重塑染色质的空间构象，在基因表达的汪洋中掀起波澜，最终决定了肿瘤这艘巨轮的航向。 研究人员在1,294种血浆代谢物和1,396种尿液 ...

State Key Laboratory of Natural and Biomimetic Drugs, Department of Molecular and Cellular Pharmacology, School of Pharmaceutical Sciences, Chemical Biology Center, Peking University, Beijing 100191, ...

Pull requests help you collaborate on code with other people. As pull requests are created, they’ll appear here in a searchable and filterable list. To get started, you should create a pull request.

Abstract: In this paper, we propose a missing data reconstruction method based on the improved CGAN model for the problem of missing measurement data in the inventory system of manufacturing ...

The ability of natural selection to optimize traits depends on the topology of the genotype-fitness map (fitness landscape). Epistatic interactions produce rugged fitness landscapes, where adaptation ...

The old economic and social growth model, characterized by centralized fossil energy consumption, is progressively shifting, and the third industrial revolution, represented by new energy and Internet ...

Abstract: In the computer vision community, great progresses have been achieved in salient object detection from natural scene images (NSI-SOD); by contrast, salient object detection in optical remote ...

such a technique. In this paper, in terms of non-functional testing, we re-define the worst case of some algorithms, re- spectively. By using genetic algorithms (GAs), we illustrate the strategies ...

Meiotic recombination is known to vary over 1,000-fold in many eukaryotic organisms, including maize. This regional genomic variation has enormous consequences for plant breeders, who rely on meiotic ...