Background: PHD2-haplodeficient macrophages (MØs) are promising candidates for the treatment of ischemia-related conditions due to their capacity to modulate the ischemic microenvironment. However, ...

高血压肾病（Hypertensive Nephropathy, HN）是慢性高血压引起的进行性肾脏疾病，是全球终末期肾病（ESRD）的主要原因之一。尽管抗高血压药物如血管紧张素转换酶抑制剂（ACEI）和血管紧张素受体阻滞剂（ARB）在控制血压方面取得了显著进展，但部分患者仍会出现 ...

本研究针对骨再生中血管化不足的难题，开发了负载PEI/PHD2 siRNA复合物的PLGA-生物活性玻璃支架。通过沉默缺氧诱导因子HIF-1α的关键负调控因子PHD2，显著增强人脐静脉内皮细胞（HUVEC）的血管生成能力和人乳牙干细胞（SHED）的成骨分化。该双功能支架为颅颌面骨 ...

In this valuable study, Taber et al. used a battery of biophysical and structural approaches to characterize the impact of erythrocytosis-related mutations in prolyl hydroxylase domain protein 2 (PHD2 ...

本研究首次揭示抗缺血药物曲美他嗪（TMZ）通过调控PHD2/HIF-1α/HO-1信号轴改善高血压肾病（HN）的新机制。实验表明TMZ能下调 ...

Community driven content discussing all aspects of software development from DevOps to design patterns. Git isn’t hard to learn. Moreover, with a Git GUI such as Atlassian’s Sourcetree, and a SaaS ...

Windows 11 is available for download worldwide. Microsoft has released it as a free upgrade, which means you do not need to pay to upgrade your computer to Windows 11. It is available for free ...

自 PHD2 首次搭载英伟达 GB200 超级计算机以来，这款行业首款 224Gbps 背板解决方案便迅速成为 AI 硬件的黄金标准。在 GTC 2025 ...