Today's mini been is here! Role of Digoxin as a Cardiac Drug Digoxin inhibits sodium-potassium ATPase exchange transporter leading to increased intra-cardiac calcium and thus contractility and decreased heart rate. Dr. Luis Verduzco discusses the use of digoxin for chronic heart failure as well as atrial fibrillation rate control. It has a narrow therapeutic index, and its elimination is by the renal route. Its goal concentration is less than 0.9 ng/L and higher risk when hypokalemia (digoxin co